Article
Pharmacokinetic considerations related to therapeutic drug monitoring of tacrolimus in kidney transplant patients.
Expert opinion on drug metabolism & toxicology - 1 Dec 2017
Andrews Louise M, Li Yi, De Winter Brenda C M, Shi Yun-Ying, Baan Carla C, Van Gelder Teun, Hesselink Dennis A
Abstract excerpt
INTRODUCTION: Tacrolimus (Tac) is the cornerstone of immunosuppressive therapy after solid organ transplantation and will probably remain so. Excluding belatacept, no new immunosuppressive drugs were registered for the prevention of acute rejection during the last decade. For several immunosuppressive drugs, clinical development halted because they weren't sufficiently effective or more toxic. Areas covered:...
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