Article
Moderating effects of preoperative knee pain and pain catastrophizing on the relation between COMT rs4680 genotypes and chronic postsurgical pain in total knee arthroplasty patients.
Anaesthesia, critical care & pain medicine - 1 Apr 2024
Li Zihua, Shi Yan, Chen Xujuan, Wu Qiting, Xi Huiqin, Tian Meimei
Abstract excerpt
BACKGROUND: The Catechol-O-methyltransferase (COMT) gene, responsible for encoding an enzyme crucial in the metabolism of catecholamines, is known to play a significant role in pain perception. Polymorphisms within this gene, particularly the COMT rs4680 genotypes, have been linked to various acute pain phenotypes. This prospective cohort study examines interactions among the genetic polymorphism COMT rs4680...
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