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Article

A common polymorphism of COMT was associated with symptomatic lumbar disc herniation based on a large sample with Chinese Han ancestry.

Scientific reports - 29 Aug 2018

Liu Hongliang, Zhao Hongmou, Li Zhong, Xue Hanzhong, Lu Jun, Ma Wei

Abstract excerpt

Lumbar disc herniation (LDH) is a common spine disease characterized by a tear in the disc ring and bulges out at the soft portion. COMT is a protein coding gene located at 22q11.21, and its gene product is a major mammalian enzyme involved in the degradation of catecholamines. A total of 2,678 study subjects with Chinese Han ancestry were recruited and 15 SNPs were selected for genotyping in our study subjects....

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Source

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Identifiers

PMID: 30158547
DOI: 10.1038/s41598-018-31240-9
PMCID: PMC6115408

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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