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Article

A novel catechol-O-methyltransferase variant associated with human disc degeneration.

International journal of medical sciences - 1 Jan 2014

Gruber Helen E, Sha Wei, Brouwer Cory R, Steuerwald Nury, Hoelscher Gretchen L, Hanley Edward N

Abstract excerpt

BACKGROUND: Disc degeneration and its associated low back pain are a major health care concern causing disability with a prominent role in this country's medical, social and economic structure. Low back pain is devastating and influences the quality of life for millions. Low back pain lifetime prevalence approximates 80% with an estimated direct cost burden of $86 billion per year. Back pain patients incur higher...

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Share to Catechol O-Methyltransferase
Share to COMT gene

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Association Studies

Share to Intervertebral Disc Degeneration

Share to Low Back Pain

Share to Polymorphism, Single Nucleotide

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Source

Open in PubMed Open full text

Identifiers

PMID: 24904231
DOI: 10.7150/ijms.8770
PMCID: PMC4045795

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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