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Article

Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration.

The Journal of biological chemistry - 28 Jul 1995

Atherton J C, Cao P, Peek R M, Tummuru M K, Blaser M J, Cover T L

Abstract excerpt

Approximately 50% of Helicobacter pylori strains produce a cytotoxin, encoded by vacA, that induces vacuolation of eukaryotic cells. Analysis of a clinically isolated tox- strain (Tx30a) indicated secretion of a 93-kDa product from a 3933-base pair vacA open reading frame. Characterization of 59 different H. pylori isolates indicated the existence of three different families of vacA signal sequences (s1a, s1b,...

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PMID: 7629077
DOI: 10.1074/jbc.270.30.17771

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