Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration.

doi:10.1074/jbc.270.30.17771

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Article

Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration.

The Journal of biological chemistry - 28 Jul 1995

Atherton J C, Cao P, Peek R M, Tummuru M K, Blaser M J, Cover T L

Abstract excerpt

Approximately 50% of Helicobacter pylori strains produce a cytotoxin, encoded by vacA, that induces vacuolation of eukaryotic cells. Analysis of a clinically isolated tox- strain (Tx30a) indicated secretion of a 93-kDa product from a 3933-base pair vacA open reading frame. Characterization of 59...

Topics

Adult
Aged
Aged, 80 and over
Alleles
Amino Acid Sequence
Antigens, Bacterial
Bacterial Proteins
Bacterial Toxins
Base Sequence
Cloning, Molecular
Cytotoxins
DNA Primers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

Helicobacter pylori

Humans

Middle Aged

Molecular Sequence Data

Mosaicism

Source

Open in PubMed

Identifiers

PMID: 7629077
DOI: 10.1074/jbc.270.30.17771

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7629077-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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