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VacA promotes CagA accumulation in gastric epithelial cells during Helicobacter pylori infection

4 Jan 2019

Abstract excerpt

Helicobacter pylori (H. pylori) is the causative agent of gastric cancer, making it the only bacterium to be recognized as a Class I carcinogen by the World Health Organization. The virulence factor cytotoxin associated gene A (CagA) is a known oncoprotein that contributes to the development of gastric cancer. The other major virulence factor vacuolating cytotoxin A (VacA), disrupts endolysosomal vesicular...

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PMID: 30631092
DOI: 10.1038/s41598-018-37095-4

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