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Article

Role of vacuolating cytotoxin A in Helicobacter pylori infection and its impact on gastric pathogenesis.

Expert review of anti-infective therapy - 1 Oct 2020

Ansari Shamshul, Yamaoka Yoshio

Abstract excerpt

Introduction Helicobacter pylori causes, via the influence of several virulence factors, persistent infection of the stomach, which leads to severe complications. Vacuolating cytotoxin A (VacA) is observed in almost all clinical strains of H. pylori; however, only some strains produce the toxigenic and pathogenic VacA, which is influenced by the gene sequence variations. VacA exerts its action by causing cell...

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Identifiers

PMID: 32536287
DOI: 10.1080/14787210.2020.1782739

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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