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Article

Structure of the repulsive guidance molecule (RGM)-neogenin signaling hub.

Science (New York, N.Y.) - 5 Jul 2013

Bell Christian H, Healey Eleanor, van Erp Susan, Bishop Benjamin, Tang Chenxiang, Gilbert Robert J C, Aricescu A Radu, Pasterkamp R Jeroen, Siebold Christian

Abstract excerpt

Repulsive guidance molecule family members (RGMs) control fundamental and diverse cellular processes, including motility and adhesion, immune cell regulation, and systemic iron metabolism. However, it is not known how RGMs initiate signaling through their common cell-surface receptor, neogenin (NEO1). Here, we present crystal structures of the NEO1 RGM-binding region and its complex with human RGMB (also called...

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Share to Biophysical Phenomena
Share to Cell Adhesion Molecules, Neuronal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Conserved Sequence

Share to Crystallography, X-Ray

Share to Membrane Proteins

Share to Oligopeptides

Share to Protein Structure, Tertiary

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Source

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Identifiers

PMID: 23744777
DOI: 10.1126/science.1232322
PMCID: PMC4730555

Genes

NEO1
RGMB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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