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Article

Generic residue numbering of the GAIN domain of adhesion GPCRs

2024-07-19

Abstract excerpt

<title>Abstract</title> <p>The GPCR autoproteolysis inducing (GAIN) domain is an ancient protein fold ubiquitous in adhesion G protein-coupled receptors (aGPCR). It contains a concealed tethered agonist element, which is necessary and sufficient for receptor activation. The GAIN domain is a hotspot for pathological mutations. However, the low primary sequence conservation of GAIN domains has thus far hindered the...

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Literature Corpus work
efcf53d2-7c09-5c52-8ab2-719dd0b726b0
DOI
10.21203/rs.3.rs-4761600/v1
Open publication

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Generic residue numbering of the GAIN domain of adhesion GPCRsDOI 10.21203/rs.3.rs-4761600/v1
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