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Article

The constitutive activity of the adhesion GPCR GPR114/ADGRG5 is mediated by its tethered agonist.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2016

Wilde Caroline, Fischer Liane, Lede Vera, Kirchberger Jürgen, Rothemund Sven, Schöneberg Torsten, Liebscher Ines

Abstract excerpt

Adhesion GPCRs (aGPCRs) form the second largest, yet most enigmatic class of the GPCR superfamily. Although the physiologic importance of aGPCRs was demonstrated in several studies, the majority of these receptors is still orphan with respect to their agonists and signal transduction. Recent studies reported that aGPCRs are activated through a tethered peptide agonist, coined the Stachel sequence. The Stachel...

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Amino Acid Sequence
Chlorocebus aethiops
COS Cells
Gene Expression Regulation
Multigene Family

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Isoforms

Receptors, G-Protein-Coupled

Tissue Distribution

Source

Identifiers

PMID: 26499266
DOI: 10.1096/fj.15-276220

Genes

ADGRG5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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