Article

Dystroglycan proteolysis is conformationally-regulated and disrupted by disease-associated mutations

2018-03-09

Abstract excerpt

The adhesion receptor dystroglycan provides a critical mechanical link between the extracellular matrix (ECM) and the actin cytoskeleton to help muscle cells withstand contraction and neural cells maintain the blood brain barrier. Disrupting the link is associated with diseases such as cancer and muscular dystrophy. Proteolysis of dystroglycan by Matrix Metalloproteases (MMPs) also breaks the mechanical anchor and...

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Literature Corpus work: cb01b49a-3978-5aa0-a11c-03d280e88005
DOI: 10.1101/279315

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