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Article

Pharmacogenetic determinants of statin-induced reductions in C-reactive protein.

Circulation. Cardiovascular genetics - 1 Feb 2012

Chu Audrey Y, Guilianini Franco, Barratt Bryan J, Nyberg Fredrik, Chasman Daniel I, Ridker Paul M

Abstract excerpt

BACKGROUND: In randomized trials, statins reduce plasma levels of C-reactive protein (CRP) and low-density lipoprotein cholesterol (LDL-C), and the magnitude of event reduction relates to on-treatment levels of both. However, whether different mechanisms underlie statin-induced CRP and LDL-C reduction is unknown. METHODS AND RESULTS: We performed a study to evaluate potential genetic determinants of CRP response...

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Share to ATP Binding Cassette Transporter, Subfamily G, Member 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ATP-Binding Cassette Transporters

Share to C-Reactive Protein

Share to Cholesterol, LDL

Share to Hydroxymethylglutaryl-CoA Reductase Inhibitors

Share to Rosuvastatin Calcium

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Source

Identifiers

PMID: 22230323
DOI: 10.1161/CIRCGENETICS.111.961847

Genes

CRP
ABCG2
APOE
LPA
PTPN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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