CoREST acts as a positive regulator of Notch signaling in the follicle cells of Drosophila melanogaster.

doi:10.1242/jcs.089797

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Article

CoREST acts as a positive regulator of Notch signaling in the follicle cells of Drosophila melanogaster.

Journal of cell science - 15 Jan 2012

Domanitskaya Elena, Schüpbach Trudi

Abstract excerpt

The Notch signaling pathway plays important roles in a variety of developmental events. The context-dependent activities of positive and negative modulators dramatically increase the diversity of cellular responses to Notch signaling. In a screen for mutations affecting the Drosophila melanogaster follicular epithelium, we isolated a mutation in CoREST that disrupts the Notch-dependent mitotic-to-endocycle switch...

Topics

Animals
Co-Repressor Proteins
Drosophila Proteins
Drosophila melanogaster
Epithelial Cells
Female
Gene Dosage
Histones
Mitosis
Mutation
Nuclear Proteins
Oocytes
Oogenesis
Phenotype
Proteolysis
Receptors, Notch
Sequence Deletion
Signal Transduction

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Identifiers

PMID: 22331351
DOI: 10.1242/jcs.089797
PMCID: PMC3283875

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