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Article

Effects of hypo-O-GlcNAcylation on Drosophila development.

The Journal of biological chemistry - 11 May 2018

Mariappa Daniel, Ferenbach Andrew T, van Aalten Daan M F

Abstract excerpt

Post-translational modification of serine/threonine residues in nucleocytoplasmic proteins with GlcNAc (O-GlcNAcylation) is an essential regulatory mechanism in many cellular processes. In Drosophila, null mutants of the Polycomb gene O-GlcNAc transferase (OGT; also known as super sex combs (sxc)) display homeotic phenotypes. To dissect the requirement for O-GlcNAc signaling in Drosophila development, we used...

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Identifiers

PMID: 29588363
DOI: 10.1074/jbc.RA118.002580
PMCID: PMC5950000

Genes

OGT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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