Effects of hypo-O-GlcNAcylation on Drosophila development.

doi:10.1074/jbc.RA118.002580

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Article

Effects of hypo-O-GlcNAcylation on Drosophila development.

The Journal of biological chemistry - 11 May 2018

Mariappa Daniel, Ferenbach Andrew T, van Aalten Daan M F

Abstract excerpt

Post-translational modification of serine/threonine residues in nucleocytoplasmic proteins with GlcNAc (O-GlcNAcylation) is an essential regulatory mechanism in many cellular processes. In Drosophila, null mutants of the Polycomb gene O-GlcNAc transferase (OGT; also known as super sex combs (sxc)) display homeotic phenotypes. To dissect the requirement for O-GlcNAc signaling in Drosophila development, we used...

Topics

Acetylglucosamine
Acylation
Alleles
Animals
CRISPR-Cas Systems
Drosophila
Drosophila Proteins
Eye Proteins
Gene Editing
Genes, Insect
Genes, Lethal
Homozygote
Male
Mutation
N-Acetylglucosaminyltransferases
Phenotype
Polycomb-Group Proteins
Signal Transduction

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PMID: 29588363
DOI: 10.1074/jbc.RA118.002580
PMCID: PMC5950000

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