Article
Mouse models of atherosclerosis.
Science (New York, N.Y.) - 3 May 1996
Breslow J L
Abstract excerpt
As a species the mouse is highly resistant to atherosclerosis. However, through induced mutations it has been possible to develop lines of mice that are susceptible to this disease. For example, mice that are deficient in apolipoprotein E, a ligand important in lipoprotein clearance, develop athe...
Topics
- Animals
- Apolipoproteins B
- Apolipoproteins E
- Arteriosclerosis
- Cholesterol, Dietary
- Dietary Fats
- Disease Models, Animal
- Genetic Predisposition to Disease
- Humans
- Mice
- Mice, Inbred Strains
- Mice, Knockout
- Mice, Transgenic
- Mutation
- Receptors, LDL