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Article

Mouse models of atherosclerosis and their suitability for the study of myocardial infarction.

Basic research in cardiology - 30 Nov 2020

Golforoush Pelin, Yellon Derek M, Davidson Sean M

Abstract excerpt

Atherosclerotic plaques impair vascular function and can lead to arterial obstruction and tissue ischaemia. Rupture of an atherosclerotic plaque within a coronary artery can result in an acute myocardial infarction, which is responsible for significant morbidity and mortality worldwide. Prompt reperfusion can salvage some of the ischaemic territory, but ischaemia and reperfusion (IR) still causes substantial...

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Identifiers

PMID: 33258000
DOI: 10.1007/s00395-020-00829-5
PMCID: PMC7704510

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