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Article

Hair follicle disruption facilitates pathogenesis to UVB-induced cutaneous inflammation and basal cell carcinoma development in Ptch(+/-) mice.

The American journal of pathology - 1 May 2014

Xu Jianmin, Weng Zhiping, Arumugam Aadithya, Tang Xiuwei, Chaudhary Sandeep C, Li Changzhao, Christiano Angela M, Elmets Craig A, Bickers David R, Athar Mohammad

Abstract excerpt

Hairless mice carrying homozygous mutations in hairless gene manifest rudimentary hair follicles (HFs), epidermal cysts, hairless phenotype, and enhanced susceptibility to squamous cell carcinomas. However, their susceptibility to basal cell carcinomas (BCCs), a neoplasm considered originated from HF-localized stem cells, is unknown. To demonstrate the role of HFs in BCC development, we bred Ptch(+/-)/C57BL6 with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24631180
DOI: 10.1016/j.ajpath.2014.01.013
PMCID: PMC4005987

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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