Inherited variants in the MC1R gene and survival from cutaneous melanoma: a BioGenoMEL study.

doi:10.1111/j.1755-148X.2012.00982.x

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Article

Inherited variants in the MC1R gene and survival from cutaneous melanoma: a BioGenoMEL study.

Pigment cell & melanoma research - 1 May 2012

Davies John R, Randerson-Moor Juliette, Kukalizch Kairen, Harland Mark, Kumar Rajiv, Madhusudan Srinivasan, Nagore Eduardo, Hansson Johan, Höiom Veronica, Ghiorzo Paola, Gruis Nelleke A, Kanetsky Peter A, Wendt Judith, Pjanova Dace, Puig Susana, Saiag Philippe, Schadendorf Dirk, Soufir Nadem, Okamoto Ichiro, Affleck Paul, García-Casado Zaida, Ogbah Zighereda, Ozola Aija, Queirolo Paola, Sucker Antje, Barrett Jennifer H, van Doorn Remco, Bishop D Timothy, Newton-Bishop Julia

Abstract excerpt

Inherited MC1R variants modulate MITF transcription factor signaling, which in turn affects tumor cell proliferation, apoptosis, and DNA repair. The aim of this BioGenoMEL collaborative study in 10 melanoma cohorts was to test the hypothesis that inherited variants thereby moderate survival expectation. A survival analysis in the largest cohort (Leeds) was carried out adjusting for factors known to impact on...

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Identifiers

PMID: 22325793
DOI: 10.1111/j.1755-148X.2012.00982.x
PMCID: PMC3490389

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MITF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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