MC1R genotype as a predictor of early-onset melanoma, compared with self-reported and physician-measured traditional risk factors: an Australian case-control-family study.

doi:10.1186/1471-2407-13-406

Article

MC1R genotype as a predictor of early-onset melanoma, compared with self-reported and physician-measured traditional risk factors: an Australian case-control-family study.

BMC cancer - 4 Sept 2013

Cust Anne E, Goumas Chris, Vuong Kylie, Davies John R, Barrett Jennifer H, Holland Elizabeth A, Schmid Helen, Agha-Hamilton Chantelle, Armstrong Bruce K, Kefford Richard F, Aitken Joanne F, Giles Graham G, Bishop D, Newton-Bishop Julia A, Hopper John L, Mann Graham J, Jenkins Mark A

Abstract excerpt

BACKGROUND: Melanocortin-1 receptor (MC1R) gene variants are very common and are associated with melanoma risk, but their contribution to melanoma risk prediction compared with traditional risk factors is unknown. We aimed to 1) evaluate the separate and incremental contribution of MC1R genotype to prediction of early-onset melanoma, and compare this with the contributions of physician-measured and self-reported...

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MC1R genotype as a predictor of early-onset melanoma, compared with self-reported and physician-measured traditional risk factors: an Australian case-control-family study.

Abstract excerpt

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