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Article

PRKCB is associated with calcineurin inhibitor-induced renal dysfunction in heart transplant recipients.

Pharmacogenetics and genomics - 1 May 2012

Lachance Kim, Barhdadi Amina, Mongrain Ian, Normand Valérie, Zakrzewski Marcin, Leblanc Marie-Hélène, Racine Normand, Carrier Michel, Ducharme Anique, Turgeon Jacques, Dubé Marie-Pierre, Phillips Michael S, White Michel, de Denus Simon

Abstract excerpt

OBJECTIVES: Single nucleotide polymorphisms (SNPs) in the transforming growth factor-β1 gene (TGFB1) have been inconsistently associated with calcineurin inhibitor (CNI)-induced renal dysfunction following cardiac transplantation. The impact of genetic variants related to the renin-angiotensin-aldosterone system (RAAS) and natriuretic peptides, which are implicated in CNI nephrotoxicity, is unknown. The primary...

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Source

Identifiers

PMID: 22322241
DOI: 10.1097/FPC.0b013e3283510a35

Genes

PRKCB
TGFB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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