Article
Association between a TGFBR2 gene polymorphism (rs2228048, Asn389Asn) and acute rejection in Korean kidney transplantation recipients.
Immunological investigations - 1 Jan 2013
Kim Yeong-Hoon, Kim Tae Hee, Kang Sun Woo, Kim Hyun Ju, Park Seok Ju, Jeong Kyung Hwan, Kim Su Kang, Lee Sang Ho, Ihm Chun Gyoo, Lee Tae Won, Moon Ju Young, Yoon Young Chul, Chung Joo-Ho
Abstract excerpt
Transforming growth factor-β (TGF-β) signaling transduction initiates TGF-β activation, resulting in activation of TGF-β receptor II (TGFBR2). Any quantitative and qualitative changes in TGFBR2 are expected to affect the TGF-β signaling pathway, which occupies a central position with respect to the regulation of cell growth, differentiation, apoptosis, immune reaction, angiogenesis and extracellular matrix...
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