Article
A candidate gene approach of the calcineurin pathway to identify variants associated with clinical outcomes in renal transplantation.
Pharmacogenomics - 1 Mar 2016
Pouché Lucie, Koitka Matthias, Stojanova Jana, Woillard Jean-Baptiste, Monchaud Caroline, Villeneuve Claire, Essig Marie, Abraham Julie, Le Meur Yannick, Rerolle Jean-Phillippe, Kamar Nassim, Rostaing Lionel, Merville Pierre, Gandia Peggy, Bouchet Stephane, Petersen Britt-Sabina, Marquet Pierre, Picard Nicolas
Abstract excerpt
AIM: To investigate the potential influence of variants in genes involved in the calcineurin pathway on the efficacy and toxicity of calcineurin inhibitors in renal transplantation. MATERIALS & METHODS: Twenty-three polymorphisms in thirteen genes were tested in 381 renal transplant recipients receiving ciclosporin (n = 221) or tacrolimus (n = 160) and mycophenolate mofetil. Data were collected prospectively over...
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