Article
Two types of C/EBPα mutations play distinct but collaborative roles in leukemogenesis: lessons from clinical data and BMT models.
Blood - 6 Jan 2011
Kato Naoko, Kitaura Jiro, Doki Noriko, Komeno Yukiko, Watanabe-Okochi Naoko, Togami Katsuhiro, Nakahara Fumio, Oki Toshihiko, Enomoto Yutaka, Fukuchi Yumi, Nakajima Hideaki, Harada Yuka, Harada Hironori, Kitamura Toshio
Abstract excerpt
Two types of mutations of a transcription factor CCAAT-enhancer binding protein α (C/EBPα) are found in leukemic cells of 5%-14% of acute myeloid leukemia (AML) patients: N-terminal mutations expressing dominant negative p30 and C-terminal mutations in the basic leucine zipper domain. Our results showed that a mutation of C/EBPα in one allele was observed in AML after myelodysplastic syndrome, while the 2 alleles...
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