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Article

Promoter methylation in coagulation <i>F7</i> gene influences plasma FVII concentrations and relates to coronary artery disease

7 Feb 2012

Abstract excerpt

BACKGROUND: Plasma factor VII concentrations (FVIIa), a marker of coronary artery disease (CAD) risk, are influenced by genetic markers at the promoter site: the A2 allele, due to a 10bp insertion at position -323, is a determinant of lower FVIIa concentrations and reduced CAD risk, while the -402A allele, due to a G>A substitution, confers increased transcriptional activity in vitro resulting in higher FVIIa....

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PMID: 22315437
DOI: 10.1136/jmedgenet-2011-100195

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