Article
A functional haplotype in the 5' flanking region of the factor VII gene is associated with an increased risk of coronary heart disease.
Journal of thrombosis and haemostasis : JTH - 1 Oct 2003
Carew J A, Basso F, Miller G J, Hawe E, Jackson A A, Humphries S E, Bauer K A
Abstract excerpt
AIMS: The aim of this study was to investigate associations between coronary heart disease risk and polymorphisms in the coagulation factor (F)VII gene in participants of a large prospective study. METHODS: One thousand nine hundred and fifty-seven men were genotyped for four FVII polymorphisms, -670A-->C, -402G-->A, a 10 base pair insertion at -323 (0 > 10) in the promoter, and R353Q in the structural gene....
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