Article
Contribution of factor VII genotype to activated FVII levels. Differences in genotype frequencies between northern and southern European populations.
Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 1997
Bernardi F, Arcieri P, Bertina R M, Chiarotti F, Corral J, Pinotti M, Prydz H, Samama M, Sandset P M, Strom R, Garcia V V, Mariani G
Abstract excerpt
The relationship between coagulation factor VII (FVII) levels in plasma and FVII genotypes, determined by three polymorphisms (5'F7, IVS7, and 353R/Q), were studied in 500 control subjects enrolled in European multicenter study. The selection of particular FVII genotypes and the analysis of variance clearly indicated the independent contribution of a single 5'F7 insertion (A2) or 353Q (M2) allele to lowering...
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