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Article

Modulation of factor VII levels by intron 7 polymorphisms: population and in vitro studies.

Blood - 1 Jun 2000

Pinotti M, Toso R, Girelli D, Bindini D, Ferraresi P, Papa M L, Corrocher R, Marchetti G, Bernardi F

Abstract excerpt

Previous studies have established that factor VII gene (F7) polymorphisms (5'F7 and R353Q) contribute about one-third of factor VII (FVII) level variation in plasma. However, F7 genotyping in patients with cardiovascular disease has produced conflicting results. Population and expression studies...

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PMID: 10828024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10828024-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Modulation of factor VII levels by intron 7 polymorphisms: population and in vitro studies.PMID 10828024Read ↗

Molecular mechanisms of FVII deficiency: expression of mutations clustered in the IVS7 donor splice site of factor VII gene.Semantic proximity Read ↗

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Molecular analysis of the genotype-phenotype relationship in factor VII deficiency.Semantic proximity Read ↗

Genetic architecture of the F7 gene in a Spanish population: implication for mapping complex diseases and for functional assays.Semantic proximity Read ↗

Promoter methylation in coagulation <i>F7</i> gene influences plasma FVII concentrations and relates to coronary artery diseaseSemantic proximity Read ↗

Complexity of the genetic contribution to factor VII deficiency in two Spanish families: clinical and biological implications.Semantic proximity Read ↗

Population genetic and phylogenetic evidence for positive selection on regulatory mutations at the factor VII locus in humans.Semantic proximity Read ↗

Coagulation factor VII gene haplotypes, obesity-related traits, and cardiovascular risk in young women.Semantic proximity Read ↗

Functional analysis of the genetic variability in the F7 gene promoter.Semantic proximity Read ↗

Next-generation sequencing and recombinant expression characterized aberrant splicing mechanisms and provided correction strategies in factor VII deficiencySemantic proximity Read ↗

Novel aberrant splicings caused by a splice site mutation (IVS1a+5g>a) in F7 gene.Semantic proximity Read ↗

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