Article
Complexity of the genetic contribution to factor VII deficiency in two Spanish families: clinical and biological implications.
Haematologica - 1 Aug 2003
Sabater-Lleal Maria, Martínez-Marchán Elisabeth, Martínez-Sánchez Elisabeth, Coll Mmaculada, Vallvé Cristina, Mateo José, Souto Joan Carles, Fontcuberta Jordi, Soria José Manuel
Abstract excerpt
BACKGROUND AND OBJECTIVES: Although many F7 DNA variants have been described to be associated with alterations in factor VII (FVII) levels, the correlation of functional levels of FVII with disease (i.e. bleeding) is highly variable indicating that other factors are likely involved in producing this phenotype. DESIGN AND METHODS: We studied two unrelated Spanish families, identified from two asymptomatic...
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