Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An in vivo pilot study characterizing the new CYP2A67, 8, and *10 alleles.

Biochemical and biophysical research communications - 11 Jan 2002

Xu C, Rao Y S, Xu B, Hoffmann E, Jones J, Sellers E M, Tyndale R F

Abstract excerpt

We developed genotyping assays for CYP2A6*7 (Ile471Thr) and CYP2A6*8 (Arg485Leu). We found higher allelic frequencies in Japanese and Chinese versus Caucasians and identified an allele in which both substitutions occur together (CYP2A6*10). We created a homology model for predicting the impact of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Area Under Curve
Share to Aryl Hydrocarbon Hydroxylases
Share to Cotinine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2A6

Share to Cytochrome P-450 Enzyme System

Share to Mixed Function Oxygenases

Share to Nicotine

Source

Identifiers

PMID: 11779172
DOI: 10.1006/bbrc.2001.6209

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-11779172-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An in vivo pilot study characterizing the new CYP2A6*7, *8, and *10 alleles.PMID 11779172Read ↗

Functional characterization of allelic variants of polymorphic human cytochrome P450 2A6 (CYP2A6*5, *7, *8, *18, *19, and *35).Semantic proximity Read ↗

Characterization of novel CYP2A6 polymorphic alleles (CYP2A6*18 and CYP2A6*19) that affect enzymatic activity.Semantic proximity Read ↗

A novel polymorphism of human CYP2A6 gene CYP2A6*17 has an amino acid substitution (V365M) that decreases enzymatic activity in vitro and in vivo.Semantic proximity Read ↗

Functional variants at CYP2A6: new genotyping methods, population genetics, and relevance to studies of tobacco dependence.Semantic proximity Read ↗

CYP2A7 polymorphic alleles confound the genotyping of CYP2A6*4A allele.Semantic proximity Read ↗

Functional characterization of novel rare CYP2A6 variants and potential implications for clinical outcomes.Semantic proximity Read ↗

A novel CYP2A6 allele (CYP2A6*35) resulting in an amino-acid substitution (Asn438Tyr) is associated with lower CYP2A6 activity in vivo.Semantic proximity Read ↗

Functional Characterization of 34 CYP2A6 Allelic Variants by Assessment of Nicotine C-Oxidation and Coumarin 7-Hydroxylation Activities.Semantic proximity Read ↗

A novel single nucleotide polymorphism altering stability and activity of CYP2a6.Semantic proximity Read ↗

Genetic polymorphisms in human CYP2A6 gene causing impaired nicotine metabolism.Semantic proximity Read ↗

Characterization of a novel CYP2A7/CYP2A6 hybrid allele (CYP2A6*12) that causes reduced CYP2A6 activity.Semantic proximity Read ↗

Genetic variability in CYP2A6 and the pharmacokinetics of nicotine.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.