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Article

Ultra-deep sequencing of HIV-1 reverse transcriptase before start of an NNRTI-based regimen in treatment-naive patients.

Virology - 25 Apr 2012

Messiaen Peter, Verhofstede Chris, Vandenbroucke Ina, Dinakis Sylvie, Van Eygen Veerle, Thys Kim, Winters Bart, Aerssens Jeroen, Vogelaers Dirk, Stuyver Lieven J, Vandekerckhove Linos

Abstract excerpt

There are conflicting data on the impact of low frequency HIV-1 drug-resistant mutants on the response of first-line highly active antiretroviral therapy (HAART), more specifically containing a NNRTI. As population sequencing does not detect resistant viruses representing less than 15-25% of the viral population, more sensitive techniques have been developed but still need clinical validation. We evaluated...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 22305619
DOI: 10.1016/j.virol.2012.01.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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