Article
Assessment of Transmitted HIV-1 Drug Resistance Mutations Using Ultra- Deep Pyrosequencing in a Turkish Cohort.
Current HIV research - 1 Jan 2018
Sili Uluhan, Aksu Burak, Tekin Aysun, Hasdemir Ufuk, Soyletir Guner, Korten Volkan
Abstract excerpt
BACKGROUND: Antiretroviral treatment (ART) reduces morbidity and mortality caused by human immunodeficiency virus (HIV) infection; however, the emergence of drug-resistant strains poses an important obstacle to treatment success. Using conventional sequencing methods to determine antiretroviral resistance, mutations present in ≥20% of quasispecies can be identified, but drug-resistant minority variants can lead...
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