Article
Contribution of human immunodeficiency virus type 1 minority variants to reduced drug susceptibility in patients on an integrase strand transfer inhibitor-based therapy.
PloS one - 1 Jan 2014
Gibson Richard M, Weber Jan, Winner Dane, Miller Michael D, Quiñones-Mateu Miguel E
Abstract excerpt
The role of HIV-1 minority variants on transmission, pathogenesis, and virologic failure to antiretroviral regimens has been explored; however, most studies of low-level HIV-1 drug-resistant variants have focused in single target regions. Here we used a novel HIV-1 genotypic assay based on deep sequencing, DEEPGEN (Gibson et al 2014 Antimicrob Agents Chemother 58∶2167) to simultaneously analyze the presence of...
Topics
- Animals
- Anti-HIV Agents
- Cell Line
- Dose-Response Relationship, Drug
- Drug Resistance, Multiple
- Drug Resistance, Viral
- Genotyping Techniques
- HIV Integrase
- HIV Integrase Inhibitors
- HIV-1
- High-Throughput Nucleotide Sequencing
- Humans
- Mice