Age-related somatic structural changes in the nuclear genome of human blood cells.

doi:10.1016/j.ajhg.2011.12.009

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Article

Age-related somatic structural changes in the nuclear genome of human blood cells.

American journal of human genetics - 10 Feb 2012

Forsberg Lars A, Rasi Chiara, Razzaghian Hamid R, Pakalapati Geeta, Waite Lindsay, Thilbeault Krista Stanton, Ronowicz Anna, Wineinger Nathan E, Tiwari Hemant K, Boomsma Dorret, Westerman Maxwell P, Harris Jennifer R, Lyle Robert, Essand Magnus, Eriksson Fredrik, Assimes Themistocles L, Iribarren Carlos, Strachan Eric, O'Hanlon Terrance P, Rider Lisa G, Miller Frederick W, Giedraitis Vilmantas, Lannfelt Lars, Ingelsson Martin, Piotrowski Arkadiusz, Pedersen Nancy L, Absher Devin, Dumanski Jan P

Abstract excerpt

Structural variations are among the most frequent interindividual genetic differences in the human genome. The frequency and distribution of de novo somatic structural variants in normal cells is, however, poorly explored. Using age-stratified cohorts of 318 monozygotic (MZ) twins and 296 single-born subjects, we describe age-related accumulation of copy-number variation in the nuclear genomes in vivo and...

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Identifiers

PMID: 22305530
DOI: 10.1016/j.ajhg.2011.12.009
PMCID: PMC3276669

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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