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Article

An integrative multi-scale analysis of the dynamic DNA methylation landscape in aging.

PLoS genetics - 1 Feb 2015

Yuan Tian, Jiao Yinming, de Jong Simone, Ophoff Roel A, Beck Stephan, Teschendorff Andrew E

Abstract excerpt

Recent studies have demonstrated that the DNA methylome changes with age. This epigenetic drift may have deep implications for cellular differentiation and disease development. However, it remains unclear how much of this drift is functional or caused by underlying changes in cell subtype composition. Moreover, no study has yet comprehensively explored epigenetic drift at different genomic length scales and in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 25692570
DOI: 10.1371/journal.pgen.1004996
PMCID: PMC4334892

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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