Article
A genome-wide linkage study of mammographic density, a risk factor for breast cancer.
Breast cancer research : BCR - 1 Jan 2011
Greenwood Celia M T, Paterson Andrew D, Linton Linda, Andrulis Irene L, Apicella Carmel, Dimitromanolakis Apostolos, Kriukov Valentina, Martin Lisa J, Salleh Ayesha, Samiltchuk Elena, Parekh Rashmi V, Southey Melissa C, John Esther M, Hopper John L, Boyd Norman F, Rommens Johanna M
Abstract excerpt
INTRODUCTION: Mammographic breast density is a highly heritable (h2 > 0.6) and strong risk factor for breast cancer. We conducted a genome-wide linkage study to identify loci influencing mammographic breast density (MD). METHODS: Epidemiological data were assembled on 1,415 families from the Australia, Northern California and Ontario sites of the Breast Cancer Family Registry, and additional families recruited in...
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