Article
A comprehensive evaluation of interaction between genetic variants and use of menopausal hormone therapy on mammographic density.
Breast cancer research : BCR - 16 Aug 2015
Rudolph Anja, Fasching Peter A, Behrens Sabine, Eilber Ursula, Bolla Manjeet K, Wang Qin, Thompson Deborah, Czene Kamila, Brand Judith S, Li Jingmei, Scott Christopher, Pankratz V Shane, Brandt Kathleen, Hallberg Emily, Olson Janet E, Lee Adam, Beckmann Matthias W, Ekici Arif B, Haeberle Lothar, Maskarinec Gertraud, Le Marchand Loic, Schumacher Fredrick, Milne Roger L, Knight Julia A, Apicella Carmel, Southey Melissa C, Kapuscinski Miroslav K, Hopper John L, Andrulis Irene L, Giles Graham G, Haiman Christopher A, Khaw Kay-Tee, Luben Robert, Hall Per, Pharoah Paul D P, Couch Fergus J, Easton Douglas F, Dos-Santos-Silva Isabel, Vachon Celine, Chang-Claude Jenny
Abstract excerpt
INTRODUCTION: Mammographic density is an established breast cancer risk factor with a strong genetic component and can be increased in women using menopausal hormone therapy (MHT). Here, we aimed to identify genetic variants that may modify the association between MHT use and mammographic density. METHODS: The study comprised 6,298 postmenopausal women from the Mayo Mammography Health Study and nine studies...
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