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Comparison of immunohistochemistry and next-generation sequencing results in oncogenic PTEN missense mutations.

Pathology, research and practice - 1 Nov 2023

Kim Moonsik, Kim Jinhee, Seo An Na, Jeong Ji Yun, Park Nora Jee-Young, Chong Gun Oh, Hong Dae Gy, Park Ji Young

Abstract excerpt

BACKGROUND: Phosphatase and tensin homolog (PTEN) is one of the most frequently mutated tumor suppressor genes in malignant tumors. Oncogenic PTEN mutations have diagnostic, prognostic, and therapeutic implications. Similar to TP53 mutations, oncogenic PTEN mutations can result from nonsynonymous missense mutations. However, there has been no detailed study on the immunostaining pattern of oncogenic PTEN missense...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to PI3K/AKT/mTOR signaling in cancer

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Identifiers

PMID: 37862920
DOI: 10.1016/j.prp.2023.154879

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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