Article
Toll-like receptor 1 polymorphisms increase susceptibility to candidemia.
The Journal of infectious diseases - 15 Mar 2012
Plantinga Theo S, Johnson Melissa D, Scott William K, van de Vosse Esther, Velez Edwards Digna R, Smith P Brian, Alexander Barbara D, Yang John C, Kremer Dennis, Laird Gregory M, Oosting Marije, Joosten Leo A B, van der Meer Jos W M, van Dissel Jaap T, Walsh Thomas J, Perfect John R, Kullberg Bart Jan, Netea Mihai G
Abstract excerpt
BACKGROUND: Candidemia is a severe invasive fungal infection with high mortality. Recognition of Candida species is mediated through pattern recognition receptors such as Toll-like receptors (TLRs). This study assessed whether genetic variation in TLR signaling influences susceptibility to candidemia. METHODS: Thirteen mostly nonsynonymous single nucleotide polymorphisms (SNPs) in genes encoding TLRs and...
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