Article
Tenascin-c renders a proangiogenic phenotype in macrophage via annexin II.
Journal of cellular and molecular medicine - 1 Jan 2018
Wang Zhiyang, Wei Qi, Han Liang, Cao Keqing, Lan Tianfeng, Xu Zhenjie, Wang Yingjuan, Gao Yuan, Xue Jing, Shan Fei, Feng Jun, Xie Xin
Abstract excerpt
Tenascin-c is an extracellular matrix glycoprotein, the expression of which relates to the progression of atherosclerosis, myocardial infarction and heart failure. Annexin II acts as a cell surface receptor of tenascin-c. This study aimed to delineate the role of tenascin-c and annexin II in macrophages presented in atherosclerotic plaque. Animal models with atherosclerotic lesions were established using ApoE-KO...
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