Detection of two novel mutations and relatively high incidence of H-RAS mutations in Vietnamese oral cancer.

doi:10.1016/j.oraloncology.2009.05.638

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Article

Detection of two novel mutations and relatively high incidence of H-RAS mutations in Vietnamese oral cancer.

Oral oncology - 1 Oct 2009

Murugan Avaniyapuram Kannan, Hong Nguyen Thi, Cuc Tran Thi Kim, Hung Nguyen Chan, Munirajan Arasambattu Kannan, Ikeda Masa-Aki, Tsuchida Nobuo

Abstract excerpt

Oral squamous cell carcinoma is the sixth most common cancer in the world and the seventh most common cancer in Vietnam. The RAS and PI3K-AKT signaling pathways play an important role in oral carcinogenesis. Our previous study on PI3K signaling pathway showed the absence of PIK3CA and PTEN gene mutations in Vietnamese oral cancer. We thus hypothesized that the RAS could be more likely activated as an upstream...

Topics

Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell
Codon
Exons
Female
Genes, ras
Humans
Male
Middle Aged
Mitogen-Activated Protein Kinase 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mouth Neoplasms

Mutation

Mutation, Missense

Polymorphism, Single Nucleotide

Risk Factors

Vietnam

Source

Open in PubMed

Identifiers

PMID: 19628422
DOI: 10.1016/j.oraloncology.2009.05.638

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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