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Article

Genetically prolonged beige fat in male mice confers long-lasting metabolic health

12 May 2023

Abstract excerpt

A potential therapeutic target to curb obesity and diabetes is thermogenic beige adipocytes. However, beige adipocytes quickly transition into white adipocytes upon removing stimuli. Here, we define the critical role of cyclin dependent kinase inhibitor 2A (Cdkn2a) as a molecular pedal for the beige-to-white transition. Beige adipocytes lacking Cdkn2a exhibit prolonged lifespan, and male mice confer long-term...

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Share to Adipokines, Inflammation, and Metabolic Diseases
Share to Adipose Tissue and Metabolism
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PMID: 37169793
DOI: 10.1038/s41467-023-38471-z

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