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Article

Calorie Restriction Prevents Metabolic Aging Caused by Abnormal SIRT1 Function in Adipose Tissues.

Diabetes - 1 May 2015

Xu Cheng, Cai Yu, Fan Pengcheng, Bai Bo, Chen Jie, Deng Han-Bing, Che Chi-Ming, Xu Aimin, Vanhoutte Paul M, Wang Yu

Abstract excerpt

Adipose tissue is a pivotal organ determining longevity, due largely to its role in maintaining whole-body energy homeostasis and insulin sensitivity. SIRT1 is a NAD-dependent protein deacetylase possessing antiaging activities in a wide range of organisms. The current study demonstrates that mice with adipose tissue-selective overexpression of hSIRT1(H363Y), a dominant-negative mutant that disrupts endogenous...

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Share to Acetyl-CoA Carboxylase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25475438
DOI: 10.2337/db14-1180

Genes

SIRT1

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