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Article

Expression of OXA-type and SFO-1 β-lactamases induces changes in peptidoglycan composition and affects bacterial fitness.

Antimicrobial agents and chemotherapy - 1 Apr 2012

Fernández Ana, Pérez Astrid, Ayala Juan A, Mallo Susana, Rumbo-Feal Soraya, Tomás Maria, Poza Margarita, Bou Germán

Abstract excerpt

β-Lactamases and penicillin-binding proteins (PBPs) have evolved from a common ancestor. β-Lactamases are enzymes that degrade β-lactam antibiotics, whereas PBPs are involved in the synthesis and processing of peptidoglycan, which forms an elastic network in the bacterial cell wall. This study analyzed the interaction between β-lactamases and peptidoglycan and the impact on fitness and biofilm production. A...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22290977
DOI: 10.1128/AAC.05402-11
PMCID: PMC3318342

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