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Article

Evolution for improved secretion and fitness may be the selective pressures leading to the emergence of two NDM alleles.

Biochemical and biophysical research communications - 9 Apr 2020

Zalucki Yaramah M, Jen Freda E-C, Pegg Cassandra L, Nouwens Amanda S, Schulz Benjamin L, Jennings Michael P

Abstract excerpt

The New Delhi metallo-β-lactamase (NDM-1) mediates resistance to β-lactam antibiotics. NDM-1 was likely formed as the result of a gene fusion between sequences encoding the first six amino acids of cytoplasm-localised aminoglycosidase, AphA6, and a periplasmic metallo-β -lactamase. We show that NDM-1 has an atypical signal peptide and is inefficiently secreted. Two new blaNDM-1 alleles that have polymorphisms in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32014252
DOI: 10.1016/j.bbrc.2020.01.135

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