Article

Divergent LD-transpeptidase-independent effects of peptidoglycan carboxypeptidases on intrinsic β-lactam and vancomycin resistance

2022-04-05

Abstract excerpt

<h4>ABSTRACT</h4> Vancomycin and β-lactams are clinically important antibiotics that inhibit the formation of peptidoglycan cross-links, but their binding targets are different. The binding target of vancomycin is D-alanine-D-alanine (D-Ala-D-Ala), whereas that of β-lactam is penicillin-binding proteins (PBPs). In this study, we revealed the divergent effects of peptidoglycan (PG) carboxypeptidases on vancomycin...

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Literature Corpus work: 08feb9ea-8b55-5300-abec-826c7f1bc3a0
DOI: 10.1101/2022.04.04.487088

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