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Article

Evolution of extended-spectrum beta-lactamases by mutation.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases - 1 Jan 2008

Gniadkowski M

Abstract excerpt

Antimicrobial resistance genes in pathogenic bacteria belong to the most rapidly evolving DNA sequences, which results in an enormous structural diversity of resistance effectors. Structural modifications of resistance genes by mutation and recombination, together with a multitude of events that stimulate their mobility and expression, allow microorganisms to survive in environments saturated with antimicrobial...

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beta-Lactam Resistance
beta-Lactamases
beta-Lactams
Escherichia coli
Evolution, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gram-Negative Bacteria

Models, Molecular

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PMID: 18154525
DOI: 10.1111/j.1469-0691.2007.01854.x

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