Article
Comparative genomics for mycobacterial peptidoglycan remodelling enzymes reveals extensive genetic multiplicity.
BMC microbiology - 24 Mar 2014
Machowski Edith Erika, Senzani Sibusiso, Ealand Christopher, Kana Bavesh Davandra
Abstract excerpt
BACKGROUND: Mycobacteria comprise diverse species including non-pathogenic, environmental organisms, animal disease agents and human pathogens, notably Mycobacterium tuberculosis. Considering that the mycobacterial cell wall constitutes a significant barrier to drug penetration, the aim of this study was to conduct a comparative genomics analysis of the repertoire of enzymes involved in peptidoglycan (PG)...
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