Article
Role of class A penicillin-binding proteins in the expression of beta-lactam resistance in Enterococcus faecium.
Journal of bacteriology - 1 Jun 2009
Rice Louis B, Carias Lenore L, Rudin Susan, Hutton Rebecca, Marshall Steven, Hassan Medhat, Josseaume Nathalie, Dubost Lionel, Marie Arul, Arthur Michel
Abstract excerpt
Peptidoglycan is polymerized by monofunctional d,d-transpeptidases belonging to class B penicillin-binding proteins (PBPs) and monofunctional glycosyltransferases and by bifunctional enzymes that combine both activities (class A PBPs). Three genes encoding putative class A PBPs (pbpF, pbpZ, and ponA) were deleted from the chromosome of Enterococcus faecium D344R in all possible combinations in order to identify...
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