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Article

Mutations in the β subunit of RNA polymerase alter intrinsic cephalosporin resistance in Enterococci.

Antimicrobial agents and chemotherapy - 1 Apr 2012

Kristich Christopher J, Little Jaime L

Abstract excerpt

As major causes of hospital-acquired infections, antibiotic-resistant enterococci are a serious public health concern. Enterococci are intrinsically resistant to many cephalosporin antibiotics, a trait that enables proliferation in patients undergoing cephalosporin therapy. Although a few genetic determinants of cephalosporin resistance in enterococci have been described, overall, many questions remain about the...

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Identifiers

PMID: 22290974
DOI: 10.1128/AAC.06077-11
PMCID: PMC3318385

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