Article

RNA polymerase mutations cause cephalosporin resistance in clinical <i>Neisseria gonorrhoeae</i> isolates

2019-05-03

Abstract excerpt

Increasing Neisseria gonorrhoeae resistance to ceftriaxone, the last antibiotic recommended for empiric gonorrhea treatment, poses an urgent public health threat. However, the genetic basis of reduced susceptibility to ceftriaxone is not completely understood: while most ceftriaxone resistance in clinical isolates is caused by target site mutations in penA , others lack these mutations. Here, we show that penA...

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Literature Corpus work: 707afd62-5764-5672-9658-9da184d78dca
DOI: 10.1101/626457

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